top of page


Effect of circadian rhythm, age, training and acute lameness on serum concentrations of cartilage oligomeric matrix protein (COMP) neo-epitope in horses

Ekman S, Lindahl A, Rüetschi U, Jansson A, Björkman K, Abrahamsson-Aurell K, Björnsdóttir S, Löfgren M, Hultén LM, Skiöldebrand E. Equine Vet J. 2019 Sep;51(5):674-680. doi: 10.1111/evj.13082. Epub 2019 Mar 6.Equine Vet J. 2019. PMID: 30739342 Free PMC article

Cartilage oligomeric matrix protein neoepitope in the synovial fluid of horses with acute lameness: A new biomarker for the early stages of osteoarthritis.

Skiöldebrand E, Ekman S, Mattsson Hultén L, Svala E, Björkman K, Lindahl A, Lundqvist A, Önnerfjord P, Sihlbom C, Rüetschi U. Equine Vet J. 2017 Sep;49(5):662-667. doi: 10.1111/evj.12666. Epub 2017 Feb 28.Equine Vet J. 2017. PMID: 28097685 Free PMC article.

An inflammatory equine model demonstrates dynamic changes of immune response and cartilage matrix molecule degradation in vitro.

Svala E, Löfgren M, Sihlbom C, Rüetschi U, Lindahl A, Ekman S, Skiöldebrand E. Connect Tissue Res. 2015;56(4):315-25. doi: 10.3109/03008207.2015.1027340. Epub 2015 Apr 22.Connect Tissue Res. 2015. PMID: 25803623

Enhanced concentration of COMP (cartilage oligomeric matrix protein) in osteochondral fractures from racing Thoroughbreds.

Skiöldebrand E, Heinegård D, Eloranta ML, Nilsson G, Dudhia J, Sandgren B, Ekman S. J Orthop Res. 2005 Jan;23(1):156-63. doi: 10.1016/j.orthres.2004.05.013.J Orthop Res. 2005. PMID: 15607888 Free article.

Altered homeostasis of extracellular matrix proteins in joints of standardbred trotters during a long-term training programme.

Skiöldebrand E, Heinegård D, Eloranta ML, Nilsson G, Dudhia J, Sandgren B, Ekman S. J Orthop Res. 2005 Jan;23(1):156-63. doi: 10.1016/j.orthres.2004.05.013.J Orthop Res. 2005. PMID: 15607888 Free article.

Ultrastructural immunolocalisation of bone sialoprotein in the osteocartilagenous interface of the equine third carpal bone.

Ekman S, Skiöldebrand E, Heinegård D, Hultenby K.Ekman S, et al. Equine Vet J. 2005 Jan;37(1):26-30. doi: 10.2746/0425164054406937.Equine Vet J. 2005. PMID: 15651730

Ex vivo magnetic resonance imaging of the distal row of equine carpal bones: assessment of bone sclerosis and cartilage damage.

Anastasiou A, Skioldebrand E, Ekman S, Hall LD. Anastasiou A. Vet Radiol Ultrasound. 2003 Sep-Oct;44(5):501-12. doi: 10.1111/j.1740-8261.2003.tb00498.x.Vet Radiol Ultrasound. 2003. PMID: 14599160

Ultrastructural immunolocalization of cartilage oligomeric matrix protein (COMP) in the articular cartilage on the equine third carpal bone in trained and untrained horses.

Skiöldebrand E, Ekman S, Heinegård D, Hultenby K. Res Vet Sci. 2010 Apr;88(2):251-7. doi: 10.1016/j.rvsc.2009.07.011. Epub 2009 Aug 28.Res Vet Sci. 2010. PMID: 19716571

Concentration of collagen, aggrecan and cartilage oligomeric matrix protein (COMP) in synovial fluid from equine middle carpal joints.

Skiöldebrand E, Lorenzo P, Zunino L, Rucklidge GJ, Sandgren B, Carlsten J, Ekman S. Equine Vet J. 2001 Jul;33(4):394-402. doi: 10.2746/042516401776249480.Equine Vet J. 2001. PMID: 11469774

Anti-inflammatory effects induced by ultralow concentrations of bupivacaine in combination with ultralow concentrations of sildenafil (Viagra) and vitamin D3 on inflammatory reactive brain astrocytes.

Elisabeth Hansson, Eva Skiöldebrand, PLoS One. 2019; 14(10): e0223648. Published online 2019 Oct 9. doi: 10.1371/journal.pone.0223648

Elevated Glucose Levels Preserve Glucose Uptake, Hyaluronan Production, and Low Glutamate Release Following Interleukin-1β Stimulation of Differentiated Chondrocytes

Victoria Rotter Sopasakis, Ruth Wickelgren, Valentina Sukonina, Camilla Brantsing, Emilia Svala, Elisabeth Hansson, Sven Enerbäck, Anders Lindahl, Eva Skiöldebrand

Cartilage. 2019 Oct; 10(4): 491–503. Published online 2018 Apr 27. doi: 10.1177/1947603518770256

Biochemical alterations in inflammatory reactive chondrocytes: evidence for intercellular network communication

Eva Skiöldebrand, Anna Thorfve, Ulrika Björklund, Pegah Johansson, Ruth Wickelgren, Anders Lindahl, Elisabeth Hansson

Heliyon. 2018 Jan; 4(1): e00525. Published online 2018 Feb 1. doi: 10.1016/j.heliyon.2018.e00525

Inflammatory activation of human cardiac fibroblasts leads to altered calcium signaling, decreased connexin 43 expression and increased glutamate secretion

Eva Skiöldebrand, Annika Lundqvist, Ulrika Björklund, Mikael Sandstedt, Anders Lindahl, Elisabeth Hansson, Lillemor Mattsson Hultén

Heliyon. 2017 Oct; 3(10): e00406. Published online 2017 Oct 3. doi: 10.1016/j.heliyon.2017.e00406

Serotonin-evoked cytosolic Ca2+ release and opioid receptor expression are upregulated in articular cartilage chondrocytes from osteoarthritic joints in horses

Eva Skiöldebrand, Cecilia Ley, Ulrika Björklund, Anders Lindahl, Elisabeth Hansson

Vet Anim Sci. 2019 Dec; 8: 100078. Published online 2019 Sep 27. doi: 10.1016/j.vas.2019.100078

Anti-inflammatory effects induced by pharmaceutical substances on inflammatory active brain astrocytes—promising treatment of neuroinflammation

Elisabeth Hansson, Ulrika Björklund, Eva Skiöldebrand, Lars Rönnbäck

J Neuroinflammation. 2018; 15: 321. Published online 2018 Nov 17. doi: 10.1186/s12974-018-1361-8

Therapeutic innovation: Inflammatory-reactive astrocytes as targets of inflammation

Elisabeth Hansson, Tony Werner, Ulrika Björklund, Eva Skiöldebrand

IBRO Rep. 2016 Dec; 1: 1–9. Published online 2016 Jun 23. doi: 10.1016/j.ibror.2016.06.001

Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation

Elisabeth Hansson, Eva Skiöldebrand

J Inflamm (Lond) 2015; 12: 44. Published online 2015 Jul 25. doi: 10.1186/s12950-015-0091-2

bottom of page